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Caspase 3 抗体

This anti-Caspase 3 antibody is a 兔 多克隆 antibody detecting Caspase 3 in FACS. Suitable for 人.
产品编号 ABIN2665464
发货至: 中国

Quick Overview for Caspase 3 抗体 (ABIN2665464)

抗原

See all Caspase 3 (CASP3) 抗体
Caspase 3 (CASP3)

适用

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宿主

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克隆类型

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多克隆

标记

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This Caspase 3 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS)

克隆位点

Poly6341
  • 纯化方法

    The antibody was purified by affinity chromatography.
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % gelatin.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze.

    储存条件

    4 °C

    储存方法

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原

    Caspase 3 (CASP3)

    别名

    Caspase 3

    背景

    Caspase 3 is a member of the peptidase family C14. This cytoplasmic caspase functions as a heterotetramer and has two isoforms (one acts as a dominant negative inhibitor). The pro-form of this caspase is approximately 32 kD. Caspase 3 is involved in the caspase activation cascade responsible for apoptosis execution. Caspase 3 is inhibited by c-IAP1, c-IAP2, XIAP, survivin, and Livin and activated by Caspase 6, -8 , and -10, granzyme B, Apaf-1 by cleavage into large p17 and small p12 subunits. Caspase 3 has been shown to cleave PARP, huntingtin, androgen receptor, atrophin-1, DNA- PKcs, D4-GDI, hnRNPs C1/C2, U1snRNP, PKC delta, ATM, fodrin, gelsolin, ICAD, RIP, X-IAP, STAT1, topoisomerase I, vimentin, Rb, lamin B, mdm2, and β-catenin. The poly6341 antibody has been shown to be useful for western blotting, immunoprecipitation and immunohistochemistry of human Human caspase-3 precursor.

    途径

    Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
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